Designed for flexibility, our innovative duct occluder options conform to a variety of duct sizes while achieving complete patent ductus arteriosus (PDA) closure from a pulmonary or aortic approach.
SWITCH TO THE REFERRAL VIEW For more information specific to neonatology regarding PDA closure
PDA CLOSURE IN INFANTS
Constriction of the ductus arteriosus is a critical step in postnatal circulatory transition. If the ductus remains open, PDA occurs, resulting in left-to-right shunting that can create significant challenges, especially in premature infants.
Challenges include3:
- Pulmonary over-circulation in lungs that are already under duress
- Systemic hypoperfusion
As the only PDA closure solution indicated for premature infants ≥ 700g + ≥ 3 days old and proven to deliver safe and effective closure, Amplatzer Piccolo™ Occluder offers new opportunities to care for a wider range of patients than ever before.4
PDA CLOSURE IN ADULTS
PDA closure is recommended if left atrial or left ventricular enlargement is present and attributable to the PDA with left-toright shunt, pulmonary artery systolic pressure < 50% systemic, and pulmonary vascular resistance less than one-third systemic.5
PDA closure may be considered in the presence of a net left-to-right shunt if pulmonary artery systolic pressure is ≥ 50% systemic, and/or pulmonary vascular resistance is greater than one-third systemic.5
Transcatheter PDA closure—e.g., with an Amplatzer™ Ductus Occluder—is the standard of care in most cases.6
IRIE PATIENT STORY
“I would definitely consider Abbott’s Piccolo device to be Irie’s life saver.”
Crissa Felkner (Irie’s mom)
Toddler Irie was treated with an Amplatzer Piccolo™ device when she was just 6 weeks old.
Hub
- Data on file at Abbott.
- Philip R, Waller BR III, Agrawal V et al. Morphologic characterization of the patent ductus arteriosus in the premature infant and the choice of transcatheter occlusion device. Catheter Cardiovasc Interv. 2016;87(2): 310–317. doi.org/10.1002/ccd.26287.
- Schneider DJ, Moore JW. Patent ductus arteriosus. Circulation. 2006;114(17):1873-1882. doi.org/10.1161/CIRCULATIONAHA.105.592063.
- Amplatzer Piccolo™ Occluder Instructions for Use.
- Stout KK, Daniels CJ, Aboulhosn JA et al. 2018 AHA/ACC Guideline for the Management of Adults with Congenital Heart Disease: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2019;139(14):e698–e800. doi.org/10.1161/CIR.0000000000000603.
- Baruteau A-E, Hascoët S, Baruteau J et al. Transcatheter closure of patent ductus arteriosus: past, present and future. Arch Cardiovasc Dis. 2014;107(2):122–132.
doi.org/10.1016/j.acvd.2014.01.008. - Data on File, 302350-001_G Amplatzer™ Duct Occluder CER.
- Saliba Z, El-Rassi I, Abi-Warde MT et al. The Amplatzer Duct Occluder II: a new device for percutaneous ductus arteriosus closure. J Interven Cardiol. 2009;22(6):496–502.
doi.org/10.1111/j.1540-8183.2009.00504.x. - Gruenstein DH, et al. Transcatheter closure of patent ductus arteriosus using the Amplatzer™ Duct Occluder II (ADO II). Catheter Cardiovasc Interv. 2017;89(6):1118-1128. doi.org/10.1002/ccd.26968.